Clinico-basic Assay of Fibrinolysis

Basic and clinical aspects of fibrinolysis and thrombolysis.

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

BACKGROUND Owing to the rarity, the general demographics, basic clinico-pathologic features, management, outcome and prognostic factors of spindle cell carcinoma (SpCC) were unexplored. METHODS A SEER analysis was performed with 2336 cases (1973-2016). RESULTS A peak incidence occurred at 70~80 years without any gender predominance and 83.13% occurred in white people. The respiratory system...

Biological role of fibrinolysis.

Fibrinolysis is a basic defence mechanism of the organism designed to control the deposition of fibrin in the vascular system and elsewhere. When thrombin is generated by the coagulation system it acts on fibrinogen and 'precipitates' it out of solution as a polymer-fibrin. This polymer deposition is regulated by the fibrinolytic system which acts on the insoluble protein fibrin and, by splitti...

Natural inhibitors of fibrinolysis.

Pharmacology of fibrinolysis.

Fibrinolytic therapy has an expanding role in the treatment of many thromboembolic disorders. Four fibrinolytic drugs are currently marketed: streptokinase, anisoylated plasminogen-streptokinase activator complex, urokinase, and recombinant human tissue-type plasminogen activator. All 4 of these drugs activate the fibrinolytic system by converting plasminogen to the active enzyme, plasmin. Plas...